Chuck Bartowski (Zachary Levi) is in his mid twenties, working at a dead-end job as a computer service expert at a Burbank, California, consumer-electronics chain store with his best friend, Morgan Grimes (Joshua Gomez). Chuck is intelligent, but lacks ambition. His sister, Ellie (Sarah Lancaster), and her boyfriend, Devon "Captain Awesome" Woodcomb (Ryan McPartlin), are doctors who constantly encourage Chuck to make progress in his professional and romantic life.
Bryce Larkin (Matthew Bomer), Chuck's former Stanford University roommate and now a Central Intelligence Agency (CIA) agent, steals the Intersect, the entire merged database of the CIA and National Security Agency (NSA), and destroys the computer storing it. The sole surviving copy becomes subliminally embedded in Chuck's brain via encoded images when he opens an email from Bryce. The NSA's Major John Casey (Adam Baldwin) and CIA Agent Sarah Walker (Yvonne Strahovski) are dispatched to investigate.
Chuck is recruited to use the knowledge he now possesses to help thwart assassins and international terrorists, upending his previously mundane life. The Intersect causes Chuck to receive involuntary "flashes" of information from the database, activated by triggers such as faces, voices, objects, and keywords. In order to protect his family and friends, Chuck must keep his second occupation a secret. Casey and Walker are assigned to watch over Chuck. They are forced to establish an uneasy alliance and cover identities; Walker poses as Chuck's girlfriend and takes a job at a fast food restaurant near the Buy More, while Casey reluctantly becomes part of the Buy More sales team.
The main antagonists driving the plot are a series of rogue spy cabals, first internal to the United States intelligence community and then global in scope, and a core part of the threat is the danger of the Intersect being either captured, making Chuck as much a liability as an asset to the government, or replicated, making Chuck obsolete or outmatched by less scrupulous spies.
Started watching this show and it's actually pretty amazing. Would recommend to someone who likes good comedy/action.